Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

This paper focuses on extant approaches to counteract the consumption of fake news online. Proponents of structural approaches suggest that our proneness to consuming fake news could only be reduced by reshaping the architecture of online environments. Proponents of educational approaches suggest that fake news consumers should be empowered to improve their epistemic agency. In this paper, we address a question that is relevant to this debate: namely, whether fake news consumers commit mistakes for which they can be criticized and (...) that they could easily avoid by reforming their doxastic conduct. Proponents of structural approaches, like R. Rini and B. Millar, have defended in different ways a negative answer to this question. In this paper, we criticize their views and suggest that individual users could improve on their epistemic practice by widening their information diet. (shrink)

The book sets out to analyse the notion of a priori justification and of a priori knowledge.

This study explores social enterprises’ strategies for addressing mission drift. Relying on an inductive comparative case study of two Italian social enterprises, we show how stakeholder engagement combined with social accounting can successfully support a social venture to re-balance its positioning between wealth generation and social value creation. Indeed, stakeholder engagement helps the internal actors of a social enterprise to rationalize and embody pro-social values previously abandoned, while social accounting reinforces this embodiment process by showing the reintroduced social commitment of (...) the social enterprise to external audiences. Conversely, strategies focused only on social accounting and without significant engagement of external stakeholders prove to be unsuccessful in counterbalancing mission drift because they fail to activate the necessary process of internal re-introduction and operationalization of pro-social values and objectives. (shrink)

You reach for the bowl with ‘sugar’ written on it only to discover, from the bad taste of your coffee, that it contained salt. Mundane experiences like these show that epistemic justification does not necessarily hold stable across possible changes of information. One can be justified in believing a proposition at a certain time (that the bowl contains sugar) and cease to be justified at a later time, as one enlarges one’s epistemic perspective (as one drinks a salty coffee). When (...) this happens, one’s justification has been defeated. An epistemic defeater, broadly speaking, is that in terms of which the defeat of justification proceeds. The notion of an epistemic defeater is mostly associated with J. Pollock’s work on reasoning and inference. Pollock has provided the canonical definition of an epistemic defeater and proposed an influential taxonomy in terms of the way different types of defeaters induce their characteristic effects. The notion of an epistemic defeater has acquired a broader meaning in current epistemology, and several distinctions have been introduced that have contributed to a more nuanced understanding of the phenomenon of defeat as well as to complement Pollock’s original taxonomy. The correlated notion of a propositional defeater, defined in terms of would-be defeat of justification, is appealed to by the proponents of the defeasibility theory in the parallel debate about knowledge to explain what prevents a justified true belief from constituting knowledge in Gettier cases. (shrink)

First aim of this paper is to show that Evidentialism, when paired with a Psychologistic ontology of evidence, is unable to account for ordinary cases of inferential justification. As many epistemologists have maintained, however, when it is paired with a Propositionalist ontology of evidence, Evidentialism is unable to explain in a satisfactory way ordinary cases of perceptual justification. So, the Evidentialist is faced with a dilemma. Second aim of this paper is to give an argument in favour of Propositionalism about (...) evidence, and so to motivate the conclusion that perceptual justification must be accounted for in non-evidentialist terms. By this I do not mean to defend a strongly Non-Evidentialist epistemology, according to which there are doxastic attitudes which are unsupported by any justifier. More modestly, I aim to motivate the weakly Non-Evidentialist epistemology according to which a subject’s perceptual beliefs may be justified by non-evidential justifiers. I conclude the paper by explaining why I believe that Pryor's dogmatism supplies a model for the way in which an internalist who is persuaded by my argument might want to detail her weakly Non-Evidentialist account of perceptual justification. (shrink)

ABSTRACT:In this study, we investigate how different internal and external stakeholders influence the innovation strategy of a social enterprise to adopt product, process, and partnership innovations that impact either social or commercial performance. Relying on survey data from a sample of work integration social enterprises, we find that in situations of turbulence, administrative leaders do not significantly influence the innovation strategy of a social enterprise. Instead, board members and external stakeholders seem to play a role. Our study contributes to strategic (...) and business ethics research on social enterprises and, more broadly, to the literature that explores how business organizations combine social value creation and wealth generation. (shrink)

L’epistemologia (detta anche filosofia della conoscenza o gnoseologia) è la disciplina filosofica che studia come gli esseri umani si rapportano da un punto di vista cognitivo alla realtà che li circonda. Le questioni fondamentali che la interessano sono principalmente di natura normativa. Riguardano il modo in cui dovremmo regolare le nostre credenze alla luce dell’informazione in nostro possesso, e la natura della conoscenza umana ed i suoi limiti. Questo capitolo è organizzato in modo corrispondente. La prima sezione tratta della nozione (...) di giustificazione epistemica, la seconda quella di conoscenza, e la terza introduce il problema filosofico dello scetticismo. (shrink)

The scope of this essay, dealing with the relationship between the celebrated Canadian theologian B. Lonergan and his debt to the theological and cultural inheritance from Thomas Aquinas, is to underline three important facts. Firstly, to focus on the vital, but not exclusive, influence of Lonergan's Thomist studies , placing them in the setting of his entire work. Secondly, to explore the continuing role of the theological paradigm, worked on for decades, emerging from his doctoral thesis on operative grace in (...) St. Thomas . The current appearance of unpublished Latin texts from Lonergan's first period of academic teaching will be of special help in this regard. Thirdly, there is the desire to bring theology back to its genuine role as advancement in wisdom of Christian faith and as a service of mediation between revealed meanings and those stemming from human cultures. What St. Thomas did for the Christian world of the 13th century remained for Lonergan an example to follow in the new context of a world largely distant from faith and from Christian thought in the 20th and 21st centuries. Lonergan's key contribution is the forging of a basic and general methodology, where the anthropological and philosophical foundation is an updated expansion of the authentic contribution of the medieval Doctor. (shrink)

Graphical AbstractEnormous efforts and resources are being invested in the search for biomarkers for early cancer detection. However, the biology and genetics of cancer, an extremely heterogeneous disease from the molecular viewpoint, thwart the clinical application of laboratory discoveries, and the sought-for pan-cancer biomarkers for population screening remain out of reach. Notwithstanding advances made using artificial intelligence to overcome current limitations in cancer biomarker research, in article number 1900122, Tommaso A. Dragani et al. speculate that there is still a (...) long way to go before this important public health goal is achieved. (shrink)

Starting from the text Cibo ed etica by Franco Riva, this contribution intends to discuss the many questions raised by food ethics by questioning the thought of G.W.F. Hegel and F.W.J. Schelling. In dialogue with these two authors, the essay insists on the category of “hunger” as a characteristic trait of human ontology insofar as it is a figure of the original extroversion and openness to the other.

Thousands of candidate cancer biomarkers have been proposed, but so far, few are used in cancer screening. Failure to implement these biomarkers is attributed to technical and design flaws in the discovery and validation phases, but a major obstacle stems from cancer biology itself. Oncogenomics has revealed broad genetic heterogeneity among tumors of the same histology and same tissue (or organ) from different patients, while tumors of different tissue origins also share common genetic mutations. Moreover, there is wide intratumor genetic (...) heterogeneity among cells within any single neoplasm. These findings seriously limit the prospects of finding a single biomarker with high specificity for early cancer detection. Current research focuses on developing biomarker panels, with data assessment by machine‐learning algorithms. Whether such approaches will overcome the inherent limitations posed by tumor biology and lead to tests with true clinical value remains to be seen. (shrink)

According to Hartry Field, the mathematical Platonist is hostage of a dilemma. Faced with the request of explaining the mathematicians’ reliability, one option could be to maintain that the mathematicians are reliably responsive to a realm populated with mathematical entities; alternatively, one might try to contend that the mathematical realm conceptually depends on, and for this reason is reliably reflected by, the mathematicians’ (best) opinions; however, both alternatives are actually unavailable to the Platonist: the first one because it is in (...) tension with the idea that mathematical entities are causally ineffective, the second one because it is in tension with the suggestion that mathematical entities are mind-independent. John Divers and Alexander Miller have tried to reject the conclusion of this argument—according to which Platonism is inconsistent with a satisfactory epistemology for arithmetic—by redescribing the second horn of the dilemma in light of Crispin Wright’s notion of judgment-dependent truth; in particular they have contended that once arithmetical truth is conceived in this way the Platonist can have a substantial epistemology which does not conflict with the idea that the mathematical entities exist mind-independently. In this paper I analyze Wright’s notion of judgment-dependent truth, and reject Divers and Miller’s argument for the conclusion that arithmetical truth can be so characterized. In the final part, I address the worry that my argument generalizes very quickly to the conclusion that no area of discourse could be characterized as judgment-dependent. As against this conclusion, I indicate under what conditions—notably not satisfied in Divers and Miller’s case, but possibly satisfied in others—a discourse’s judgment-dependency can be successfully vindicated. (shrink)

This paper attempts to construct a short epistemology of economic models by using as a benchmark a comparison between the methodological issues of contemporary physics and of economics. In particular, the paper focuses on the role of indeterminacy in either sciences. Herein the general claim is that the models of economics fail at dealing with uncertainty as effectively as the models of natural sciences because economists did not manage to overcome the identification problem that is peculiar to economics. In this (...) respect, the paper shows that the models of economics assume an untenable determinism that derives from the notion of rationality of agents. The paper is divided in three sections: the first section deals with the issues related to assumptions in the models of physics and economics; the second section deals with the problem of uncertainty in quantum mechanics and in economics; the third section deals with the problem of causality in both sciences. Eventually, the paper concludes that several methodological problems affect the efficiency of economic models. Most importantly, the paper finds that economic models abstract too much from the reality and, thus, do not provide deep investigations of agents’ discrete choices. This is shown to affect the consistency of models and their explanatory power. (shrink)

In his article ‘God and Probability’, 1 Hugh Mellor introduced the notion of the ‘bridge-hand fallacy’, allegedly committed by those who think they can appeal to probabilities in arguments for design. I should like to give this notion another airing, partly because of its recent criticism in two interesting books - R. G. Swinburne' The Existence of God and D. J. Bartholomew's God of Chance - and partly because it seems worth asking how it fares in relation to the most (...) recent examples of design argument, namely those which appeal to the so-called ‘anthropic principle’ in cosmology. (shrink)

Tommaso Campanella’s dignitas hominis acquires its own autonomous and innovative historiographical value in recognizing the connection between mens and religion as a distinctive element of human be...

The aim of this essay is to analyze the concept of ecstasy in F. W. J. Schelling's Erlangen Lectures. In particular, I intend to show how it constitutes a significant evolution with regard to the model of reminiscence and in particular that of Mitwissenschaft, as presented in the Weltalter. The essay focuses on three aspects of the notion of ecstasy: 1) its relation to temporality, 2) its relation to interiority, and 3) its noetic value and its moral dimension. In conclusion, (...) I will show how in Erlangen a movement of progressive de-historicization and de-theosophicization of ecstasy began, culminating in the Berliner Einleitung of 1842/43. (shrink)

The present volume focuses on this wisdom of humility that characterizes Westphals thought and explores how that wisdom, expressed through the redemptive ...

The paper aims to reconstruct the final configuration of Schelling’s philosophical system from the second half of the 1840s. Particular attention is given to the Darstellung der reinrationalen Philosophie, which, according to Schelling’s intentions, was to replace the so-called Berliner Einleitung. By analyzing the different use of the notion of critique and the concept of positive philosophy in the two texts under examination, the paper shows how Schelling’s philosophy undergoes significant changes in the very last years of his life.

The aim of this essay is to examine recent contributions to Schelling research that appeared in three miscellanies in 2020. Their common thread is Schelling’s philosophy of nature, which, because of its dynamic and processual characteristics, is considered relevant in the debate on realism, philosophy of biology and environmental ethics. In the historical-philosophical field, many contributions highlight Schelling’s debt to Kant and Spinoza and his close relationship with the Romantic movement. Lastly, the essay analyses contributions concerning the Spätphilosophie, showing how (...) Schelling’s philosophy is to be considered first and foremost as historical philosophy. (shrink)

In this paper we focus on transmission and failure of transmission of warrant. We identify three individually necessary and jointly sufficient conditions for transmission of warrant, and we show that their satisfaction grounds a number of interesting epistemic phenomena that have not been sufficiently appreciated in the literature. We then scrutinise Wright’s analysis of transmission failure and improve on extant readings of it. Nonetheless, we present a Bayesian counterexample that shows that Wright’s analysis is partially incoherent with our analysis of (...) warrant transmission and prima facie defective. We conclude exploring three alternative lines of reply: developing a more satisfactory account of transmission failure, which we outline; dismissing the Bayesian counterexample by rejecting some of its assumptions; reinterpreting Wright’s analysis to make it immune to the counterexample. (shrink)

The aim of the study was to assess the effects of visual aesthetic perception on event-related potentials . Eight subjects assigned an aesthetic judgment and a 10-step beauty estimation to the target stimuli, consisting of famous artistic pictures and geometric shapes. In a further task, the subjects performed a motor response to the previously judged pictures and geometric shapes. ERPs were recorded through 54 scalp electrodes during both tasks. The P3b amplitude was increased during the categorization of the geometric shapes (...) compared to the artistic figures and during the vision of the beautiful targets preceding the motor response. The categorization of the aesthetic qualities of geometrical shapes seems to induce a higher level of attention, while a higher arousal variation was elicited by the recognition of beauty, in any form that was presented. (shrink)

A subject S's belief that Q is well-grounded if and only if it is based on a reason of S that gives S propositional justification for Q. Depending on the nature of S's reason, the process whereby S bases her belief that Q on it can vary. If S's reason is non-doxastic––like an experience that Q or a testimony that Q––S will need to form the belief that Q as a spontaneous and immediate response to that reason. If S's reason (...) is doxastic––like a belief that P––S will need to infer her belief that Q from it. The distinction between these two ways in which S's beliefs can be based on S's reasons is widely presupposed in current epistemology but––we argue in this paper––is not exhaustive. We give examples of quite ordinary situations in which a well-grounded belief of S appears to be based on S's reasons in neither of the ways described above. To accommodate these recalcitrant cases, we introduce the notion of enthymematic inference and defend the thesis that S can base a belief that Q on doxastic reasons P1, P2, …, Pn via inferring enthymematically Q from P1, P2, …, Pn. (shrink)

This book offers an introduction to the Sophists of fifth-century Athens and a new overall interpretation of their thought. Since Plato first animadverted on their activities, the Sophists have commonly been presented as little better than intellectual mountebanks - a picture which Professor Kerferd forcefully challenges here. Interpreting the evidence with care, he shows them to have been part of an exciting and historically crucial intellectual movement. At the centre of their teaching was a form of relativism, most famously expressed (...) by Protagoras as 'Man is the measure of all things', and which they developed in a wide range of views - on knowledge and argument, virtue, government, society, and the gods. On all these subjects the Sophists did far more than simply provoke Plato to thought. Their contributions were substantial and serious; they inaugurated the debate on many central philosophical questions and decisively shifted the focus of philosophical attention from the cosmos to man. (shrink)

Institutional explanations have been, and continue to be, one of the most important means of understanding the choices made by governments and other actors in society. This four volume set brings together a collection of the key readings in institutional theory and its applications to political phenomena. Although the principal focus of these readings is on institutional theory based in political science, articles from other disciplines that have been central to the development of theory in this discipline, or that have (...) substantial relevance for political phenomena, have also been included. Forming part of the SAGE Library of Political Science, this set contains a substantial overall introduction and conclusion as well as shorter introductions to each Part. It is an essential purchase for social science libraries around the world. (shrink)

Cognitive niche theories consist in a theoretical framework that is proving extremely profitable in bridging evolutionary biology, philosophy, cognitive science, and anthropology by offering an inter-disciplinary ground, laden with novel approaches and debates. At the same time, cognitive niche theories are multiple, and differently related to niche theories in theoretical and evolutionary biology. The aim of this paper is to clarify the theoretical and epistemological relationships between cognitive and ecological niche theories. Also, by adopting a constructionist approach we will try (...) to explain the shift from ecological to cognitive niches and their actual and theoretical overlaps. In order to do so, we will take two concepts expressing loose forms of causation in the interaction between organisms and their environment: the biological notion of “enablement” and the psycho-cognitive one of “affordance”. (shrink)

A quasivariety of algebras has the joint embedding property (JEP) if and only if it is generated by a single algebra A. It is structurally complete if and only if the free ℵ0‐generated algebra in can serve as A. A consequence of this demand, called ‘passive structural completeness’ (PSC), is that the nontrivial members of all satisfy the same existential positive sentences. We prove that if is PSC then it still has the JEP, and if it has the JEP and (...) its nontrivial members lack trivial subalgebras, then its relatively simple members all belong to the universal class generated by one of them. Under these conditions, if is relatively semisimple then it is generated by one ‐simple algebra. We also prove that a quasivariety of finite type, with a finite nontrivial member, is PSC if and only if its nontrivial members have a common retract. The theory is then applied to the variety of De Morgan monoids, where we isolate the sub(quasi)varieties that are PSC and those that have the JEP, while throwing fresh light on those that are structurally complete. The results illuminate the extension lattices of intuitionistic and relevance logics. (shrink)

Desde la segunda mitad del siglo XX, el concepto de “nosotros” ha pasado a caracterizar la reflexión sobre la identidad, la cultura y la filosofía iberoamericanas. La reconstrucción de la trayectoria intelectual que ha hecho madurar el análisis de este concepto en la obra de Ricardo Espinoza Lolas nos muestra cómo esta categoría del pensamiento sudamericano, a pesar de sus estrechos vínculos con la historia del continente, puede universalizarse y, por tanto, utilizarse como paradigma filosófico a nivel mundial. A través (...) de la comparación y profundización de las interpretaciones del lema “nosotros” dadas por Juan Carlos Scannone y Arturo Andrés Roig, y la ofrecida por Espinoza, emerge el alcance de una propuesta que, por un lado, muestra el valor histórico-filosófico del pensamiento iberoamericano y su papel dentro de una historia de la filosofía ya no entendida en clave meramente eurocéntrica e ideológica, sino en su desarrollo real y material; y por otro, la funcionalidad de un concepto que se convierte en dispositivo de desactivación del actual orden global capitalista de las tesis de espinozistas. (shrink)

The article offers an overview and a critical assessment of the work of Zeev Sternhell, focussing on the questions of fascism and of the anti-Enlightenment tradition. It claims that the career of the Israeli historian revolves around the intuition of a history of European modernity marked by a central opposition: that between the Enlightenment and the anti-Enlightenment. I show how the idea is already present in his initial works, and argue that it produces a specific kind of intellectual history, concerned (...) with the unity of traditions over large temporal horizons. I claim that it has the advantage of offering an historically grounded reading of fascism which nonetheless is capable to account for its emergence in apparently very dissimilar contexts. After having examined some of the shortcomings of this approach, I offer an historical explanation for the type of intellectual history practiced by Sternhell, arguing that it must be tied to his political activism in Israel. (shrink)

Neuromoral theorists are those who claim that a scientific understanding of moral judgment through the methods of psychology, neuroscience and related disciplines can have normative implications and can be used to improve the human ability to make moral judgments. We consider three neuromoral theories: one suggested by Gazzaniga, one put forward by Gigerenzer, and one developed by Greene. By contrasting these theories we reveal some of the fundamental issues that neuromoral theories in general have to address. One important issue concerns (...) whether the normative claims that neuromoral theorists would like to make are to be understood in moral terms or in non-moral terms. We argue that, on either a moral or a non-moral interpretation of these claims, neuromoral theories face serious problems. Therefore, neither the moral nor the non-moral reading of the normative claims makes them philosophically viable. (shrink)

Kant is an author who frequently recurs in Zubiri’s works. The constancy of the comparison between the two philosophers is entirely internal to the method of investigation itself of Zubrian philosophy, which has nothing properly historiographical, and which has posed many problems to the commentators of Spanish philosopher. Following the references to Zubiri’s interpretation of Kant in the philosophical texts of Ignacio Ellacuria (1930-1989), we will try to feed a two-part comparison whose main goal is to clarify the nature and (...) the perspective of the confrontation with Kantism, in relation to the more general problem of the status of philosophy in Zubiri’s production. (shrink)